PerfectBASH: Band‐selective homonuclear decoupling in peptides and peptidomimetics. (8th July 2018)

• Record Type: Journal Article
• Authors: Ilgen, Julian; Kaltschnee, Lukas; Thiele, Christina M.
• Other Names: Castañar Laura guestEditor.
• Is Part Of: Magnetic resonance in chemistry. Volume 56:Number 10(2018)
• Page Start: 918
• Page End: 933
• Publication Date: 2018-07-08
• Subjects: 1H‐NMR -- 2D NMR -- band‐selective homonuclear (BASH) decoupling -- full sensitivity -- NMR -- peptides -- peptidomimetics -- perfect echo -- pure shift; Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.4757
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract : Band selective techniques offer the highest sensitivity of all pure shift approaches and thus are the best choice for decoupling well‐separated 1 H‐frequency regions, such as the amide‐ or the α‐proton region of α‐peptides. They are inept to fully decouple the amide‐ and the α‐proton region simultaneously, though. Herein, we present a new homonuclear decoupling technique, which extends the capabilities of band selective decoupling using the perfect echo principle. This modification allows a complete backbone decoupling (amide‐ and α‐protons) in peptides and opens band selective homonuclear decoupling to substances with two mutually coupled protons in the spectral range of interest.