Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease. Issue 5 (3rd September 2018)

• Record Type: Journal Article
• Authors: Handa, Tomohiro; Matsui, Shoko; Yoshifuji, Hajime; Kodama, Yuzo; Yamamoto, Hiroshi; Minamoto, Seijiro; Waseda, Yuko; Sato, Yasuharu; Kubo, Keishi; Mimori, Tsuneyo; Chiba, Tsutomu; Hirai, Toyohiro; Mishima, Michiaki
• Is Part Of: Modern rheumatology. Volume 28:Issue 5(2018)
• Page Start: 838
• Page End: 844
• Publication Date: 2018-09-03
• Subjects: Biomarker -- IgG4-related disease -- soluble IL-2 receptor; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2017.1416739
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Objectives: Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to elucidate the clinical significance of blood markers, including sIL-2R, in patients with IgG4-RD. Methods: We enrolled 59 patients with IgG4-RD and investigated the association between blood markers (white blood cells, C-reactive protein, sIL-2R, IgG, IgG4, IgE, total hemolytic complement), and clinical indices. Results: At baseline, serum sIL-2R (Rs = 0.532, p < .001) and IgG4 (Rs = 0.545, p < .001) levels showed significant correlation to the number of organs involved. During follow-up period (median, 70 months; range, 7–195 months), 40 patients were treated with corticosteroids. Receiver operating characteristic (ROC) analysis showed that baseline sIL-2R levels most accurately predicted patients requiring glucocorticoid treatment (area under the ROC curve, 0.807). Among the 46 patients who improved, sIL-2R and IgG4 levels decreased in 42 and 41 patients, respectively. Among them, serum sIL-2R levels decreased to a normal range in 42 patients (91%), whereas IgG4 levels normalized in 19 (41%). Conclusion: The serum sIL-2R level is a potential biomarker for IgG4-RD that may reflect the number of involved organs and may predict patients requiring glucocorticoid treatment.