Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus. Issue 5 (3rd September 2018)

• Record Type: Journal Article
• Authors: Tanimura, Shun; Fujieda, Yuichiro; Kono, Michihiro; Shibata, Yuhei; Hisada, Ryo; Sugawara, Eri; Nakamura, Hiroyuki; Ohmura, Kazumasa; Shimamura, Sanae; Mitani, Asako; Shida, Haruki; Watanabe, Toshiyuki; Kato, Masaru; Oku, Kenji; Bohgaki, Toshiyuki; Amengual, Olga; Yasuda, Shinsuke; Shimizu, Chikara; Atsumi, Tatsuya
• Is Part Of: Modern rheumatology. Volume 28:Issue 5(2018)
• Page Start: 865
• Page End: 871
• Publication Date: 2018-09-03
• Subjects: CD14 -- monocyte -- presepsin (PSEP) -- systemic lupus erythematosus (SLE) -- soluble CD14-ST; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2017.1408755
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Objectives: Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis. Aberrant functions in monocyte or neutrophils are increasingly recognized in systemic lupus erythematosus (SLE). We investigated whether plasma PSEP reflects disease activity in patients with SLE. Methods: This retrospective study comprised 35 patients with SLE and 72 with non-SLE autoimmune diseases who visited our facility during the period from August 2012 to September 2015. Plasma PSEP levels and laboratory data were compared between SLE and non-SLE. Clinical markers of SLE disease activity, including SLE disease activity index 2000 (SLEDAI-2K), serum complement concentrations and serum anti-ds-DNA antibodies were assessed in correlation with plasma PSEP levels. Results: Plasma PSEP levels in SLE were higher than those in non-SLE. This phenomenon holds true when comparing SLE and non-SLE patients in the absence of infection ( p = .0008). Plasma PSEP levels in SLE patients negatively correlated with C3 ( r = –0.4454, p = .0430), CH50 ( r = –0.4502, p = .0406) and positively with SLEDAI-2K ( r = 0.4801, p = .0237). Conclusion: Elevated plasma PSEP levels were correlated with disease activity of SLE, suggesting inappropriate monocyte or neutrophil activation in the pathophysiology of SLE exacerbation.