Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3, 3-difluoro-γ-lactams. Issue 35 (29th August 2018)

• Record Type: Journal Article
• Authors: Mai, Wen-Peng; Wang, Fei; Zhang, Xiao-Feng; Wang, Shi-Min; Duan, Qun-Peng; Lu, Kui
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 35(2018)
• Page Start: 6491
• Page End: 6498
• Publication Date: 2018-08-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01389f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Enabled by nickel catalysis, the first radical tandem cyclization–arylation for the synthesis of 4-benzyl-3, 3-difluoro-γ-lactams has been developed. Abstract : Enabled by nickel catalysis, a practical access to the synthesis of 4-benzyl-3, 3-difluoro-γ-lactams has been developed via radical tandem cyclisation/arylation. This method features a nickel catalyst, high reaction efficiency, and good substrate tolerance and scope. This protocol proceeds through an intramolecular radical addition to form a primary alkyl radical followed by intermolecular Suzuki-type coupling.