ADHD-originating in the gut? The emergence of a new explanatory model. (November 2018)

• Record Type: Journal Article
• Authors: Sandgren, Anna M.; Brummer, Robert J.M.
• Is Part Of: Medical hypotheses. Volume 120(2018)
• Page Start: 135
• Page End: 145
• Publication Date: 2018-11
• Subjects: ADHD -- Enteric nervous system -- Autonomic nervous system -- Microbiome-gut-brain axis -- Explanatory model; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2018.08.022
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: The microbiome-gut-brain axis paradigm explains that alterations in the central nervous system and behavior may be secondary to functional changes in the gut in general and more specifically the enteric nervous system. An unfavorable development of the intestinal microbial ecosystem, leading to e.g. a diminished microbial diversity, may play a central role. This paper outlines, and describes the theoretical basis of, a novel integrative model explaining the etiology and pathogenesis of ADHD in a microbiota-gut-brain context, taking into account the complexity of the bi-directional signaling between the gut and the brain.