Towards the total synthesis of trichormamide A, a cyclic undecapeptide. Issue 41 (10th October 2018)

• Record Type: Journal Article
• Authors: Gaillard, Michel; Das, Sanjit; Djibo, Mahamadou; Raviglione, Delphine; Roumestand, Christian; Legrand, Baptiste; Inguimbert, Nicolas
• Is Part Of: Tetrahedron letters. Volume 59:Issue 41(2018)
• Page Start: 3713
• Page End: 3718
• Publication Date: 2018-10-10
• Subjects: Solid phase peptide synthesis -- Laxaphycin -- Trichormamide -- Lipocyclopeptide -- Cyanobacteria; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.09.010
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: First total synthesis of the natural product trichormamide A. Extension of the synthesis to a trichormamide A diastereomer. Trichormamide A synthesized through a SPPS and in solution cyclization process. Structures were studied by means of NMR and HRMS. Abstract: Lipocyclopeptides isolated from marine sources hold great promise as new lead for therapeutics. Here, we propose the first attempt towards the total synthesis of Trichormamide A. This synthesis will help to confirm the proposed structure of the cyclic lipopeptide.