Copper-catalyzed radical/radical cross-coupling of ketoxime carboxylates with 4-hydroxycoumarins: A novel synthesis of furo[3, 2-c]-coumarins. Issue 41 (10th October 2018)

• Record Type: Journal Article
• Authors: He, Mingchuang; Yan, Zhaohua; Wang, Wangyang; Zhu, Fuyuan; Lin, Sen
• Is Part Of: Tetrahedron letters. Volume 59:Issue 41(2018)
• Page Start: 3706
• Page End: 3712
• Publication Date: 2018-10-10
• Subjects: Copper-catalyzed -- Ketoxime carboxylates -- 4-Hydroxycoumarins -- Furo[3, 2-c]-coumarins; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.09.007
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An example of copper-catalyzed radical/radical cross-coupling. Reaction of ketoxime carboxylate with 4-hydroxycoumarins produces furan compounds. Diverse furo[3, 2- c ]-coumarins were smoothly synthesized in good yields. A concise and efficient synthetic method for furo[3, 2- c ]-coumarins was developed. Abstract: A novel and efficient strategy for the synthesis of furo[3, 2- c ]coumarins has been developed via copper-catalyzed radical/radical cross-coupling of ketoxime carboxylates with 4-hydroxycoumarins. This redox-neutral reaction allows smooth and selective synthesis of 2-substituted, 3-substituted, 2, 3-disubstituted and 2, 3-fused polycyclic furo[3, 2- c ]coumarins.