Adenosine methylation as a molecular imprint defining the fate of RNA. Issue 17 (31st May 2018)

• Record Type: Journal Article
• Authors: Knuckles, Philip; Bühler, Marc
• Other Names: Zavolan Mihaela guestEditor.; Gerber André guestEditor.; Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 592:Issue 17(2018)
• Page Start: 2845
• Page End: 2859
• Publication Date: 2018-05-31
• Subjects: cotranscriptional regulation -- m6A -- RNA modifications; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13107
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Multiple lines of evidence suggest the RNA modification N 6 ‐methyladonsine (m 6 A), which is installed in the nucleus cotranscriptionally and, thereafter, serves as a reversible chemical imprint that influences several steps of mRNA metabolism. This includes but is not limited to RNA folding, splicing, stability, transport and translation. In this Review we focus on the current view of the nuclear installation of m 6 A as well as the molecular players involved, the so called m 6 A writers. We also explore the effector proteins, or m 6 A readers, that decode the imprint in different cellular contexts and compartments, and ultimately, the way the modification influences the lifecycle of an RNA molecule. The wide evolutionary conservation of m 6 A and its critical role in physiology and disease warrants further studies into this burgeoning and exciting field. Abstract :