Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials. Issue 17 (11th July 2018)

• Record Type: Journal Article
• Authors: Taraballi, Francesca; Sushnitha, Manuela; Tsao, Christopher; Bauza, Guillermo; Liverani, Chiara; Shi, Aaron; Tasciotti, Ennio
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 17(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-11
• Subjects: foreign body reactions -- immune tuning materials -- implantable devices -- inflammation -- materials functionalization; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201800490
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Regenerative medicine technologies rely heavily on the use of well‐designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided. Abstract : Tissue engineering has focused on the development of therapeutic strategies that combine materials, stem cells, and biomolecules for the following goal: complete tissue regeneration. However, the immune response to these biomaterials challenges the successful implementation of these technologies. This review highlights emerging biomimetic approaches in biomaterial design that target and modulate the inflammatory environment in order to mediate tissue restoration.