Three dimensional de novo micro bone marrow and its versatile application in drug screening and regenerative medicine. (August 2015)

• Record Type: Journal Article
• Authors: Li, Guanqun; Liu, Xujun; Du, Qian; Gao, Mei; An, Jing
• Is Part Of: Experimental biology and medicine. Volume 240:Number 8(2015:Aug.)
• Page Start: 1029
• Page End: 1038
• Publication Date: 2015-08
• Subjects: Three dimension -- scaffold -- bone marrow -- stem cell -- computational model -- disease modeling -- regenerative medicine; Physiology -- Periodicals; Biology, Experimental -- Periodicals; Medicine, Experimental -- Periodicals; 610.72
• DOI: 10.1177/1535370215594583
• Languages: English
• ISSNs: 1535-3702

Abstract

The finding that bone marrow hosts several types of multipotent stem cell has prompted extensive research aimed at regenerating organs and building models to elucidate the mechanisms of diseases. Conventional research depends on the use of two-dimensional (2D) bone marrow systems, which imposes several obstacles. The development of 3D bone marrow systems with appropriate molecules and materials however, is now showing promising results. In this review, we discuss the advantages of 3D bone marrow systems over 2D systems and then point out various factors that can enhance the 3D systems. The intensive research on 3D bone marrow systems has revealed multiple important clinical applications including disease modeling, drug screening, regenerative medicine, etc. We also discuss some possible future directions in the 3D bone marrow research field.