Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity. (1st November 2016)

• Record Type: Journal Article
• Authors: Mardan-Nik, Maryam; Pasdar, Alireza; Jamialahmadi, Khadijeh; Avan, Amir; Mohebati, Mohsen; Esmaily, Habibollah; Biabangard-Zak, Atefeh; Afzal Javan, Fahimeh; Rivandi, Mahdi; Ferns, Gordon A.; Ghayour-Mobarhan, Majid
• Is Part Of: Annals of human biology. Volume 43:Number 6(2016)
• Page Start: 542
• Page End: 546
• Publication Date: 2016-11-01
• Subjects: Obesity -- heat shock protein 70 -- PCR-RFLP -- polymorphism -- coronary artery disease; Human biology -- Periodicals; 612
• DOI: 10.3109/03014460.2015.1119309
• Languages: English
• ISSNs: 0301-4460

Abstract

Abstract: Background : Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim : The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods : Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results : The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion : The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.