The RNA Response to DNA Damage. Issue 12 (19th June 2016)

• Record Type: Journal Article
• Authors: Giono, Luciana E.; Nieto Moreno, Nicolás; Cambindo Botto, Adrián E.; Dujardin, Gwendal; Muñoz, Manuel J.; Kornblihtt, Alberto R.
• Is Part Of: Journal of molecular biology. Volume 428:Issue 12(2016:Jun. 19)
• Page Start: 2636
• Page End: 2651
• Publication Date: 2016-06-19
• Subjects: ARE AU-rich sequence elements -- ARE-BP ARE-binding protein -- AS alternative splicing -- Cdk9 cyclin-dependent kinase 9 -- CIS cisplatin -- CPT camptothecin -- CTD C-terminal domain -- diRNAs DSB-induced RNAs -- DSB DNA double-strand break -- DOX doxorubicin (adriamycin) -- DDR DNA damage response -- ETO etoposide -- GADD growth arrest and DNA damage-inducible -- GGR global genome repair -- hnRNP heterogeneous nuclear ribonucleoprotein -- IR ionizing radiation -- lincRNAs long intergenic non-coding RNAs -- RNAi RNA interference -- RNAPII RNA polymerase II -- TCR transcription-coupled repair -- miRNA microRNA -- ncRNA non-protein-coding RNA -- NER nucleotide excision repair -- P-TEFb positive transcription elongation factor b -- RBP RNA binding protein -- SR proteins serine-arginine proteins; DNA damage response -- p53 -- RNA processing -- alternative splicing -- ncRNAs; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2016.03.004
• Languages: English
• ISSNs: 0022-2836

Abstract

Abstract: Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields. Graphical Abstract: Highlights: The DNA damage response is essential for genome integrity in multicellular organisms. RNAs and RNA metabolism play a prominent role in the DNA damage response (DDR). Splicing factors and RNA binding proteins are regulators of and regulated by the DDR. Small and long non-coding RNAs and miRNAs also participate in the DDR.