The Toll/NF-κB pathway in cuttlefish symbiotic accessory nidamental gland. Issue 1 (November 2015)

• Record Type: Journal Article
• Authors: Cornet, Valérie; Henry, Joël; Corre, Erwan; Le Corguillé, Gildas; Zatylny-Gaudin, Céline
• Is Part Of: Developmental and comparative immunology. Volume 53:Issue 1(2015)
• Page Start: 42
• Page End: 46
• Publication Date: 2015-11
• Subjects: Invertebrate -- Cephalopod -- Innate immunity -- Toll-like receptor -- NF-kappaB pathway -- Symbiosis -- Genital glands; Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2015.06.016
• Languages: English
• ISSNs: 0145-305X

Abstract

Abstract: The female genital apparatus of decapod cephalopods contains a symbiotic accessory nidamental gland (ANG) that harbors bacterial symbionts. Although the ANG bacterial consortium is now well described, the impact of symbiosis on Sepia officinalis innate immunity pathways remains unknown. In silico analysis of the de novo transcriptome of ANG highlighted for the first time the existence of the NF-κB pathway in S. officinalis. Several signaling components were identified, i.e. five Toll-like receptors, eight signaling cascade features, and the immune response target gene iNOS, previously described as being involved in the initiation of bacterial symbiosis in a cephalopod gland. This work provides a first key for studying bacterial symbiosis and its impact on innate immunity in S. officinalis ANG. Highlights: Toll/NF-κB pathway in the reproductive nidamental glands of Sepia officinalis. Key immune factors in symbiotic nidamental glands. Identification of five Toll-like receptors.