Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study. (May 2016)

• Record Type: Journal Article
• Authors: Andersson, Charlotte; Enserro, Danielle; Sullivan, Lisa; Wang, Thomas J.; Januzzi, James L.; Benjamin, Emelia J.; Vita, Joseph A.; Hamburg, Naomi M.; Larson, Martin G.; Mitchell, Gary F.; Vasan, Ramachandran S.
• Is Part Of: Atherosclerosis. Volume 248(2016)
• Page Start: 245
• Page End: 251
• Publication Date: 2016-05
• Subjects: Vascular stiffness -- Endothelial function -- Biomarkers -- ST2 -- GDF-15 -- Troponin I -- General population; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2016.02.013
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s)ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 ± 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007–0.081] standard deviation [SD] change per SD increase in loge [GDF-15], p = 0.02) and FW (0.076 [0.026–0.126] SD change per SD increase in loge [GDF-15], p = 0.003) and inversely related to FMD (−0.051 [−0.101–0.0003] SD change per SD increase in loge [GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005–0.063] SD change per SD increase in loge [sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (−0.041 [−0.082–0.0004] SD change per SD increase in loge [hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure. Highlights: GDF-15, sST2, and hs-TnI are associated with incident cardiovascular disease (CVD), yet the underlying mechanisms are not fully understood. We showed that GDF-15, sST2, and hs-TnI are related to several measures indicative of subclinical vascular dysfunction. These findings may contribute to the associations between circulating GDF-15, sST2, and hs-TnI and incident CVD.