Ischemic Conditioning in Kidney Transplantation. (July 2017)

• Record Type: Journal Article
• Authors: Veighey, Kristin; MacAllister, Raymond
• Other Names: Przyklenk Karin guest-editor.; Whittaker Peter guest-editor.
• Is Part Of: Journal of cardiovascular pharmacology and therapeutics. Volume 22:Number 4(2017:Jul.)
• Page Start: 330
• Page End: 336
• Publication Date: 2017-07
• Subjects: renal -- ischemia–reperfusion injury -- heart disease; Cardiovascular pharmacology -- Periodicals; Cardiovascular system -- Diseases -- Treatment -- Periodicals; 616
• DOI: 10.1177/1074248417702893
• Languages: English
• ISSNs: 1074-2484

Abstract

Ischemia–reperfusion injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained on reperfusion, which limits the amount of tissue that can be salvaged. Ischemia–reperfusion injury is the predominant insult during kidney transplantation, contributing to graft dysfunction, increased rates of acute rejection, and reduced rejection-free graft survival. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, ischemic preconditioning, and its potential for improving kidney function following transplantation.