Cerebral vasomotor reactivity in reversible cerebral vasoconstriction syndrome. (May 2017)

• Record Type: Journal Article
• Authors: Topcuoglu, Mehmet Akif; Chan, Suk-tak; Silva, Gisele Sampaio; Smith, Eric Edward; Kwong, Kenneth K; Singhal, Aneesh Bhim
• Is Part Of: Cephalalgia. Volume 37:Number 6(2017)
• Page Start: 541
• Page End: 547
• Publication Date: 2017-05
• Subjects: Reversible cerebral vasoconstriction syndrome -- transcranial Doppler -- cerebrovascular reactivity -- breath-hold challenge -- migraine; Headache -- Periodicals; 616.8491
• DOI: 10.1177/0333102416650706
• Languages: English
• ISSNs: 0333-1024

Abstract

Background: Altered cerebrovascular tone is implicated in reversible cerebral vasoconstriction syndrome (RCVS). We evaluated vasomotor reactivity using bedside transcranial Doppler in RCVS patients. Methods: In this retrospective case-control study, middle cerebral artery (MCA) blood flow velocities were compared at rest and in response to breath-hold in RCVS ( n = 8), Migraineurs ( n = 10), and non-headache Controls ( n = 10). Hyperventilation response was measured in RCVS. Results: In RCVS, Breath Holding Index (BHI) was severely reduced in seven of eight patients and 14/16 MCAs; seven of 16 MCAs showed exhausted (BHI < 0.1) or inverted (BHI < 0) vasomotor reactivity. Mean BHI in RCVS (0.23 ± 0.5) was significantly lower than Migraine (1.52 ± 0.57) and Controls (1.51 ± 0.32), p < 0.001. Triphasic velocity responses were seen in all groups. The maximum V mean decline during the middle negative phase was −15.5 ± 9.2% in RCVS, −15.4 ± 7% in Migraine, and −10.3 ± 5% in Controls ( p = 0.04). In the late positive phase, average V mean increase was 6.2 ± 14% in RCVS, which was significantly lower ( p < 0.001) than Migraine (30.5 ± 11%) and Controls (30.2 ± 6%). With hyperventilation, RCVS patients showed 23% decrease in V mean . Conclusion: Cerebral arterial tone is abnormal in RCVS, with proximal vasoconstriction and abnormally reduced capacity for vasodilation. Further studies are needed to determine the utility of BHI to diagnose RCVS before angiographic reversibility is established, and to estimate prognosis.