New metabolites produced by Fusarium solani T-13 isolated from a dead branch. (September 2016)

• Record Type: Journal Article
• Authors: Shiono, Yoshihito; Ariefta, Nanang Rudianto; Anwar, Chairil; Matsjeh, Sabirin; Sappapan, Ruengrit; Murayama, Tetsuya; Koseki, Takuya; Kawamura, Tetsuaki; Uesugi, Shota; Kimura, Ken-ichi
• Is Part Of: Phytochemistry letters. Volume 17(2016:Sep.)
• Page Start: 232
• Page End: 237
• Publication Date: 2016-09
• Subjects: Fusarium solani -- Lasiodiplodin -- Endophytes -- Ca2+ signaling inhibition activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.08.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three novel benzenediol lactone derivatives were isolated from Fusarium solani T-13. All isolated compounds were identified by 1D-, 2D-NMR and HR-Mass techniques. Compounds 1, 3, and 4 restored the growth inhibition in mutant yeast. Abstract: Three novel benzenediol lactone derivatives, 7-hydroxy-14- de - O -methyl-lasiodiplodin (2 ), ethyl-3, 5-dihydroxy-7-(6, 8-dihydroxynonyl)benzoate (4 ), and 7-ethylbenzoate-7-heptanoic acid (5 ), together with known compounds, 14- de - O -methyl-lasiodiplodin (1 ) and ethyl-3, 5-dihydroxy-7-(8-hydroxynonyl)benzoate (3 ), were isolated from the culture of Fusarium solani T-13, a fungus from a dead branch. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compounds1, 3 and4 showed doughnut like phenotypes of growth restoring activity against the mutant yeast ( zds1 Δ erg3 Δ pdr1/3 Δ) at the concentration of 0.16, 0.63 and 1.25 μg/spot, respectively.