Microdialysis as a way to measure antibiotics concentration in tissues. (September 2016)

• Record Type: Journal Article
• Authors: Marchand, Sandrine; Chauzy, Alexia; Dahyot-Fizelier, Claire; Couet, William
• Is Part Of: Pharmacological research. Volume 111(2016:Sep.)
• Page Start: 201
• Page End: 207
• Publication Date: 2016-09
• Subjects: Microdialysis -- Distribution -- Tissue -- Antibiotics -- Pharmacokinetics -- Pharmacodynamics; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2016.06.001
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: As for all other drugs, antibiotics must reach their pharmacodynamic target in order to exert their effect, but because infection may occur in various tissues the distribution of antibiotics has always been of particular concern. In this article, we will first critically review the various methodologies available to study antibiotics tissue distribution, including microdialysis, secondly we will show how basic pharmacokinetic concepts may help to predict or interpret antibiotics tissue distribution and third we will address the question of linking antibiotics tissue distribution with their antimicrobial effect, using modern pharmacokinetic-pharmacodynamic methods.