Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease. (July 2015)

• Record Type: Journal Article
• Authors: Kumar, Ashwani; Sharma, Vishavdeep; Singh, Vijay Pal; Kaundal, Madhu; Gupta, Manish Kumar; Bariwal, Jitender; Deshmukh, Rahul
• Is Part Of: Mechanisms of ageing and development. Volume 149(2015)
• Page Start: 75
• Page End: 87
• Publication Date: 2015-07
• Subjects: cAMP cyclic adenosine monophosphate -- cGMP cyclic guanosine monophosphate -- AD Alzheimer's disease -- PDE phosphodiesterases -- Aβ amyloid beta -- NFTs neurofibrillary tangles -- FAD familial Alzheimer's disease -- SAD sporadic Alzheimer's disease -- APP amyloid precursor protein -- PS-1 presenilin -- Aβ oligomer amyloid beta oligomer -- AβPP amyloid βprecursor protein -- sAβPP soluble amyloid beta precursor protein -- ROS reactive oxygen species -- IL-1 interleukin-1 -- IL-6 interleukin-6 -- TNFα tumor necrosis factor alpha -- GDP guanosine diphosphate -- GTP guanosine triphosphate -- AC adenylyl cyclase -- GC guanylyl cyclase -- ATP adenosine triphosphate -- cAMP cyclic adenosine monophosphate -- 5′AMP 5′adenosine monophosphate -- PDE phosphodiesterase -- cGMP cyclic guanosine monophosphate -- 5′GMP 5′guanosine monophosphate -- EPAC exchange protein activated cAMP -- ERK extracellular signal- regulated kinase -- PKA protein kinase A -- PKG protein kinase G -- CREB cyclic AMP response element binding protein -- BDNF brain derived neurotrophic factor -- NGF nerve growth factor; Herbal plants -- Phosphodiesterase -- Learning and memory -- Alzheimer's disease -- Cognitive functions; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2015.05.009
• Languages: English
• ISSNs: 0047-6374

Abstract

Graphical abstract: Highlights: The potential role of PDE inhibitors in Alzheimer's dieases. Natural plants as a source of bioactive inhibitors of phosphodiesterases. Pharmacophoric features required to inhibit phosphodiesterases. Potential role of herbs in the management of AD pathology. Abstract: Cyclic nucleotides viz ., cAMP/cGMP has been well known to play important role in cellular function and deficiency in their levels has been implicated in the pathogenesis of various neurodegenerative disorders including Alzheimer's disease (AD). Phosphodiesterases (PDE) are the enzymes involved in the metabolism of cyclic nucleotides and the inhibition of phosphodiesterases is considered to be viable strategy to restore the level of cyclic nucleotides and their functions in the brain. Various synthetic PDE inhibitors had been used clinically for various disorders and also suggested to be useful candidates for treating neurological disorders. However, side effects of these synthetic PDE inhibitors have limited their use in clinical practice. Natural plant extracts or their bio-active compounds are considered to be safe and are widely acceptable. During the last decade, many plant extracts or their bio-active compounds were tested pre-clinically for PDE inhibitory activity and are reported to be equally potent in inhibiting PDE's, as that of synthetic compounds. The present review is aimed to discuss the potential plant extract/compounds with PDE inhibitory activity and critically discuss their potential role in Alzheimer's disease.