Safety and efficacy of combination therapy of interferon‐α2 and ruxolitinib in polycythemia vera and myelofibrosis. (22nd June 2018)

• Record Type: Journal Article
• Authors: Mikkelsen, Stine Ulrik; Kjær, Lasse; Bjørn, Mads Emil; Knudsen, Trine Alma; Sørensen, Anders Lindholm; Andersen, Christen Bertel Lykkegaard; Bjerrum, Ole Weis; Brochmann, Nana; Fassi, Daniel El; Kruse, Torben A.; Larsen, Thomas Stauffer; Mourits‐Andersen, Hans Torben; Nielsen, Claus Henrik; Pallisgaard, Niels; Thomassen, Mads; Skov, Vibe; Hasselbalch, Hans Carl
• Is Part Of: Cancer medicine. Volume 7:Number 8(2018:Aug.)
• Page Start: 3571
• Page End: 3581
• Publication Date: 2018-06-22
• Subjects: combination therapy -- interferon‐alpha -- myeloproliferative neoplasms -- polycythemia vera -- primary myelofibrosis -- ruxolitinib; 616.994005
• DOI: 10.1002/cam4.1619
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Interferon‐α2 reduces elevated blood cell counts and splenomegaly in patients with myeloproliferative neoplasms (MPN) and may restore polyclonal hematopoiesis. Its use is limited by inflammation‐mediated toxicity, leading to treatment discontinuation in 10‐30% of patients. Ruxolitinib, a potent anti‐inflammatory agent, has demonstrated benefit in myelofibrosis (MF) and polycythemia vera (PV) patients. Combination therapy (CT) with these two agents may be more efficacious than monotherapy with either, potentially improving tolerability of interferon‐α2 as well. We report the preliminary results from a phase II study of CT with pegylated interferon‐α2 and ruxolitinib in 50 MPN patients (PV, n = 32; low‐/intermediate‐1‐risk MF, n = 18), the majority (n = 47) being resistant and/or intolerant to interferon‐α2 monotherapy. Objectives included remission (2013 revised criteria encompassing histologic, hematologic, and clinical responses), complete hematologic response (CHR), molecular response, and toxicity. Follow‐up was 12 months. Partial remission (PR) and sustained CHR were achieved in 9% and 44% of PV patients, respectively. In MF patients, complete or partial remission was achieved in 39%, and sustained CHR in 58%. The median JAK2 V617F allele burden declined significantly in both groups. Hematologic toxicity was the most common adverse event and was managed by dose reduction. Thirty‐seven serious adverse events were recorded in 23 patients; the discontinuation rate was 20%. We conclude that CT with interferon‐α2 and ruxolitinib is efficacious in patients with low‐/intermediate‐1‐risk MF and, to a lesser extent, in patients with PV. These preliminary results encourage phase III studies as well as a study with CT in newly diagnosed MPN patients. Abstract : Combination therapy with low‐dose pegylated interferon‐α2 and ruxolitinib is feasible and efficacious in patients with low‐ and intermediate‐1‐risk myelofibrosis and, to a lesser extent, in patients with PV, who were intolerant or unresponsive to monotherapy with interferon‐α2. Sustained complete hematologic response was achieved in ≈50% of patients and the median JAK2 V617F allele burden declined significantly.