Renal cell carcinoma risk associated with lower intake of micronutrients. (2nd July 2018)

• Record Type: Journal Article
• Authors: Bock, Cathryn H.; Ruterbusch, Julie J.; Holowatyj, Andreana N.; Steck, Susan E.; Van Dyke, Alison L.; Ho, Won Jin; Cote, Michele L.; Hofmann, Jonathan N.; Davis, Faith; Graubard, Barry I.; Schwartz, Kendra L.; Purdue, Mark P.
• Is Part Of: Cancer medicine. Volume 7:Number 8(2018:Aug.)
• Page Start: 4087
• Page End: 4097
• Publication Date: 2018-07-02
• Subjects: African Americans -- carcinoma -- diet -- micronutrients -- renal cell -- vitamins; 616.994005
• DOI: 10.1002/cam4.1639
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample ( P‐ interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC. Abstract : Diets rich in micronutrients may have a protective effect on RCC development. Despite differences in underlying cancer risk attributable to race, we found that reduction of RCC risk associated with micronutrient intake is similar among both African Americans and White populations.