Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways. Issue 17 (5th September 2018)

• Record Type: Journal Article
• Authors: Bovaird, Samantha; Patel, Dhara; Padilla, Juan‐Carlos Alberto; Lécuyer, Eric
• Other Names: Zavolan Mihaela guestEditor.; Gerber André guestEditor.; Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 592:Issue 17(2018)
• Page Start: 2948
• Page End: 2972
• Publication Date: 2018-09-05
• Subjects: Cis‐regulatory elements -- RNA disease -- RNA localization -- RNA‐binding proteins; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13228
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The asymmetric subcellular distribution of RNA molecules from their sites of transcription to specific compartments of the cell is an important aspect of post‐transcriptional gene regulation. This involves the interplay of intrinsic cis‐ regulatory elements within the RNA molecules with trans‐ acting RNA‐binding proteins and associated factors. Together, these interactions dictate the intracellular localization route of RNAs, whose downstream impacts have wide‐ranging implications in cellular physiology. In this review, we examine the mechanisms underlying RNA localization and discuss their biological significance. We also review the growing body of evidence pointing to aberrant RNA localization pathways in the development and progression of diseases. Abstract :