Biologically active quinoline and quinazoline alkaloids part II. Issue 5 (27th February 2018)

• Record Type: Journal Article
• Authors: Shang, Xiao‐Fei; Morris‐Natschke, Susan L.; Yang, Guan‐Zhou; Liu, Ying‐Qian; Guo, Xiao; Xu, Xiao‐Shan; Goto, Masuo; Li, Jun‐Cai; Zhang, Ji‐Yu; Lee, Kuo‐Hsiung
• Is Part Of: Medicinal research reviews. Volume 38:Issue 5(2018)
• Page Start: 1614
• Page End: 1660
• Publication Date: 2018-02-27
• Subjects: biological activities -- camptothecin -- natural products -- quinazoline alkaloids -- quinoline alkaloids; Pharmacology -- Periodicals; Drugs -- Research -- Periodicals; 615
• DOI: 10.1002/med.21492
• Languages: English
• ISSNs: 0198-6325

Abstract

Abstract: To follow‐up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009‒2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti‐inflammatory, hepatoprotective, antioxidant, anti‐asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.