Amyloid Inhibitors: Lysine‐Derived Carbon Dots for Chiral Inhibition of Prion Peptide Fibril Assembly (Adv. Therap. 4/2018). Issue 4 (14th August 2018)

• Record Type: Journal Article
• Authors: Arad, Elad; Bhunia, Susanta Kumar; Jopp, Jürgen; Kolusheva, Sofiya; Rapaport, Hanna; Jelinek, Raz
• Is Part Of: Advanced therapeutics. Volume 1:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-14
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.201870008
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : In article number1800006, Raz Jelinek and co‐workers report that enantiomeric C‐dots, synthesized from eitherd ‐Lysine orl ‐Lysine, interfere with aggregation of the amyloidogenic determinant of the prion protein. The interactions of the chiral Lys‐C‐dots with the amyloidogenic determinant, as well as with membrane bilayers, appear to be stereoselective, with thel ‐Lys‐C‐dots inhibiting amyloidogenic aggregation more effectively thand ‐Lys‐C‐dots.