Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold. Issue 16 (20th July 2018)

• Record Type: Journal Article
• Authors: Moon, Nicholas G.; Mazzini, Fiorella; Pekkanen, Allison M.; Wilts, Emily M.; Long, Timothy E.
• Is Part Of: Macromolecular chemistry and physics. Volume 219:Issue 16(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-20
• Subjects: biomaterial -- isosorbide -- Poly(β‐thioester) -- renewable feedstock -- thiol‐michael; Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201800177
• Languages: English
• ISSNs: 1022-1352

Abstract

Abstract: The monomer isosorbide diacrylate ( i SDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tg s of the polymer products; however, polymers did not exhibit Tg s above room temperature. Incorporating the comonomer N, N ′‐methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable‐temperature fourier‐transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth. Abstract : A thiol‐Michael reaction enables the simple synthesis of a new poly(β‐thioester) derived from a bio‐based starting material and a hydrogen‐bonding comonomer with potential for application as a biomedical scaffold.