Altered expression of programmed death-ligand 1 after neo-adjuvant chemotherapy in patients with lung squamous cell carcinoma. (September 2016)

• Record Type: Journal Article
• Authors: Song, Zhengbo; Yu, Xinmin; Zhang, Yiping
• Is Part Of: Lung cancer. Volume 99(2016)
• Page Start: 166
• Page End: 171
• Publication Date: 2016-09
• Subjects: SCC squamous cell carcinoma; Programmed death-ligand 1 -- Overexpression -- Chemotherapy -- Squamous cell carcinoma -- Survival; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2016.07.013
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: We represent the first study of examining impact of chemotherapy for PD-L1 status in lung SCC. Neoadjuvant chemotherapy could up-regulate the expression of PD-L1 in lung SCC. Postoperative expression of PD-L1 is a better prognostic factor for survival in lung SCC. Abstract: Objective: Programmed death-ligand 1 (PD-L1) is known to be over-expressed in non-small cell lung cancer (NSCLC). However, the impact of chemotherapy on the altered status of PD-L1 expression has not been examined for NSCLC. The present study was intended to examine the impact of neoadjuvant chemotherapy on PD-L1 expression and its prognostic significance in lung squamous cell carcinoma (SCC). Patients and methods: Matched tumor samples were obtained from 76 SCC patients prior to and after neoadjuvant chemotherapy. The expression of PD-L1 was evaluated by immunohistochemistry. Survival analysis was performed by the Kaplan-Meier method. Results: Prior to neoadjuvant chemotherapy, PD-L1 expression was identified in 52.6% (40/76) of SCC patients while 61.8% (47/76) were positive for PD-L1 expression after neoadjuvant chemotherapy. Nine patients switched from negative to positive while another two patients' samples showed the reverse of the above result. Multivariate analysis demonstrated that postoperative expression of PD-L1 was an independent prognostic factor for overall survival (HR = 0.50, P = 0.003), but not for PD-L1 expression prior to neoadjuvant chemotherapy. Conclusion: Neoadjuvant chemotherapy may up-regulate the expression of PD-L1. As compared with the status of PD-L1 expression prior to chemotherapy, the postoperative expression of PD-L1 is a better prognostic factor for overall survival in SCC.