Epidemiology and outcomes of pretransplant methicillin‐resistant Staphylococcus Aureus screening in pediatric solid organ transplant candidates. (11th June 2018)

• Record Type: Journal Article
• Authors: Paulsen, Grant; Blum, Samantha; Danziger‐Isakov, Lara
• Is Part Of: Pediatric transplantation. Volume 22:Number 6(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-11
• Subjects: methicillin‐resistant staphylococcus aureus -- pediatric transplantation -- risk factors -- screening; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.13246
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: MRSA infection following SOT is an important cause of morbidity and mortality, but epidemiology and risk factors for colonization prior to pediatric SOT remain unclear. A retrospective cohort of SOT patients ≤21 years of age from 2009 to 2014 was evaluated. Demographics, MRSA screens, timing of transplantation, and MRSA infection were abstracted. From 2013 to 2014, 130 SOT candidates were screened or had known prior MRSA infection. Seventeen patients (13%) were MRSA colonized. Liver transplant candidates were least likely to be colonized (OR 0.22, CI:0.06‐0.81, P = .02); greatest risk of colonization was in lung (OR 18.7, CI:1.9‐182.3, P = .03), abdominal multivisceral (OR 7.5, CI:1.5‐38.6, P = .02), and cardiac patients with history of cardiothoracic surgery (OR 8.0, CI:1.7‐36.0, P = .007). In univariable analysis, African American patients were more likely to be colonized (OR 7.1, CI:2.49‐19.41, P = .0005). There were 3 early MRSA infections in screened patients, incidence of 3.9%; only one in a colonized patient. Thirteen percent of screened pediatric SOT candidates were MRSA colonized, with greatest risk in lung, multivisceral and cardiac patients with prior cardiothoracic surgery. Early MRSA infection occurred in 3.9% of transplanted patients. Cardiothoracic and multivisceral organ transplant candidates may benefit the most from targeted MRSA screening.