External beam radiation therapy combined with airway stenting leads to better survival in patients with malignant airway obstruction. Issue 9 (12th March 2018)

• Record Type: Journal Article
• Authors: Mallow, Christopher; Thiboutot, Jeffrey; Semaan, Roy; Hayes, Margaret M.; Hales, Russell; Ram, Ashwin; Feller‐Kopman, David; Lee, Hans; Yarmus, Lonny
• Is Part Of: Respirology. Volume 23:Issue 9(2018)
• Page Start: 860
• Page End: 865
• Publication Date: 2018-03-12
• Subjects: airway stent -- external beam radiotherapy -- lung cancer -- malignant airway obstruction; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.13292
• Languages: English
• ISSNs: 1323-7799

Abstract

ABSTRACT: Background and objective: Malignant airway obstruction (MAO), a common complication of patients with advanced lung cancer, causes debilitating dyspnoea and poor quality of life. Two common interventions used in the treatment of MAO include bronchoscopy with airway stenting and external beam radiotherapy (EBRT). Data are limited regarding their clinical effectiveness and overall effect on survival. Methods: A retrospective chart review of patients treated with airway stenting and/or EBRT at the Johns Hopkins Hospital for MAO between July 2010 and January 2017 was reviewed. Demographics, performance status, cancer histology, therapeutic intervention and date of death were recorded. Survival was calculated using cox regression analysis. Results: Of the 606 patients who were treated for MAO, 237 were identified as having MAO and included in the study. Sixty‐eight patients underwent rigid bronchoscopy and stenting, 102 EBRT and 67 a combined approach. Patients who underwent stenting hand an increased hazard ratio (HR) of death in comparison to those who received combination therapy (HR: 2.12, 95% CI: 1.02, 4.39), while there was a trend towards significance in the EBRT alone group in comparison to the combination therapy group (HR: 1.62, 95% CI: 0.93, 2.83). Conclusion: In this retrospective analysis, combination therapy with stenting and EBRT led to better survival in comparison to stenting or EBRT alone. Prospective cohort trials are needed to confirm these results. Abstract : Malignant airway obstruction is a complication for lung cancer patients. Multiple modalities exist for the treatment of this ailment, including airway stenting and external beam radiotherapy (EBRT). We showed retrospectively that airway stenting combined with EBRT was associated with increased survival in comparison to either treatment in isolation. See related Editorial