Renal regeneration after acute kidney injury. Issue 9 (22nd August 2018)

• Record Type: Journal Article
• Authors: Coelho, Silvia; Cabral, Guadalupe; Lopes, José A; Jacinto, António
• Is Part Of: Nephrology. Volume 23:Issue 9(2018)
• Page Start: 805
• Page End: 814
• Publication Date: 2018-08-22
• Subjects: acute kidney injury -- immune system -- inflammation -- kidney -- regeneration; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.13256
• Languages: English
• ISSNs: 1320-5358

Abstract

Summary at a Glance: This review focuses on the short and long term clinical risk factors that contribute to progression to chronic renal disease following acute insult. The probability of patient recovery, taking into consideration the aetiology of disease, and the cellular, molecular and immune response that determines tissue regeneration are discussed in detail. ABSTRACT: Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long‐term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role, first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal haemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.