Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells. Issue 8 (25th June 2018)

• Record Type: Journal Article
• Authors: Wu, Xian; Zhu, Yanhong; Huang, Wei; Li, Jingqiu; Zhang, Bixiang; Li, Zifu; Yang, Xiangliang
• Is Part Of: Advanced science. Volume 5:Issue 8(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-25
• Subjects: cancer cell sensitization -- chemo/HBO combination therapy -- Doxil -- hyperbaric oxygen -- tumor penetration; Science -- Periodicals; 505
• DOI: 10.1002/advs.201700859
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Hypoxia is a fundamental hallmark of solid tumors and helps contribute to chemotherapy resistance. Hyperbaric oxygen (HBO) therapy can overcome tumor hypoxia and promote chemotherapy antitumor efficacy; however, the simultaneous administration of some conventional chemotherapies, including doxorubicin (DOX), with HBO is considered an absolute contraindication. Here, DOX‐loaded liposome (Doxil) is coadministered with HBO to assess the safety and efficacy of this combination treatment. By overcoming tumor hypoxia, HBO not only improves Doxil tumor penetration by decreasing the collagen deposition but also sensitizes tumor cells to Doxil. As a result, the combination treatment synergistically inhibits H22 tumor growth, with a tumor inhibition rate of 91.5%. The combination of HBO with Doxil shows neither extra side effects nor promotion of tumor metastasis. These results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality. As both HBO and Doxil are routinely used, their combination could quickly translate to clinical trials for patients with hypoxic solid tumors. Abstract : Two FDA‐approved therapies, hyperbaric oxygen (HBO) and Doxil, are combined to synergistically potentiate Doxil antitumor efficacy. By overcoming tumor hypoxia, HBO improves Doxil tumor penetration by decreasing the collagen deposition and sensitizes tumor cells to Doxil. These results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality.