Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. (February 2017)

• Record Type: Journal Article
• Authors: Oh, Hee Kyong; Jeon, Se Jin; Lee, Sunhee; Lee, Hyung Eun; Kim, Eunji; Park, Se Jin; Kim, Ha Neul; Jung, Won Yong; Cheong, Jae Hoon; Jang, Dae Sik; Ryu, Jong Hoon
• Is Part Of: Journal of psychopharmacology. Volume 31:Number 2(2017)
• Page Start: 250
• Page End: 259
• Publication Date: 2017-02
• Subjects: Cognitive impairment -- mechanism of action -- mouse study -- pharmacological treatment -- prepulse inhibition -- schizophrenia -- sensorimotor gating -- startle response -- swertisin; Psychopharmacology -- Periodicals; 615.78
• DOI: 10.1177/0269881116672098
• Languages: English
• ISSNs: 0269-8811

Abstract

Swertisin, a plant-derived C-glucosylflavone, is known to have antidiabetic, anti-inflammatory and antioxidant effects. In the present study, we investigated in mice the effects of swertisin on glutamatergic dysfunction induced by dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate receptor antagonist. In the Acoustic Startle Response test, their MK-801-induced (given 0.2 mg/kg i.p.) pre-pulse inhibition deficit was significantly attenuated by the administration of swertisin (30 mg/kg p.o.). In the Novel Object Recognition Test, the recognition memory impairments that were induced by MK-801 (0.2 mg/kg, given i.p.) were also reversed by administration of swertisin (30 mg/kg p.o.). In addition, swertisin normalized the MK-801-induced elevation of phosphorylation levels of Akt and GSK-3β signaling molecules in the prefrontal cortex. These results indicated that swertisin may be useful in managing the symptoms of schizophrenia, including sensorimotor gating disruption and cognitive impairment, and that these behavioral outcomes may be related to Akt-GSK-3β signaling in the prefrontal cortex.