Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health. Issue 4 (6th April 2018)

• Record Type: Journal Article
• Authors: Mitsui, Takahiko; Araki, Atsuko; Goudarzi, Houman; Miyashita, Chihiro; Ito, Sachiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Shinohara, Nobuo; Takeda, Masayuki; Nonomura, Katsuya
• Is Part Of: American journal of human biology. Volume 30:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-06
• Subjects: Human biology -- Periodicals; Physical anthropology -- Periodicals; Biologie humaine -- Périodiques; Anthropologie physique -- Périodiques; 612
• DOI: 10.1002/ajhb.23127
• Languages: English
• ISSNs: 1042-0533

Abstract

Abstract: Objectives: We investigated the relationship between steroid hormone levels in cord blood and birth weight. Methods: Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. Results: Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females. Conclusions: Prenatal adrenal steroids as well as converting enzymes such as 11ß‐hydrosteroid dehydrogenase type 2 and 3ß‐hydrosteroid dehydrogenase may have an impact on prenatal physical development.