Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition. (8th July 2018)

• Record Type: Journal Article
• Authors: Bucci, P.; Galderisi, S.; Mucci, A.; Rossi, A.; Rocca, P.; Bertolino, A.; Aguglia, E.; Amore, M.; Andriola, I.; Bellomo, A.; Biondi, M.; Cuomo, A.; dell'Osso, L.; Favaro, A.; Gambi, F.; Giordano, G. M.; Girardi, P.; Marchesi, C.; Monteleone, P.; Montemagni, C.; Niolu, C.; Oldani, L.; Pacitti, F.; Pinna, F.; Roncone, R.; Vita, A.; Zeppegno, P.; Maj, M.
• Other Names: Patriarca Sara investigator.; Pietrafesa Daria investigator.; Aiello Carmen investigator.; Longo Luisa investigator.; Barone Marina investigator.; Romano Raffaella investigator.; Atti Anna Rita investigator.; Barlati Stefano investigator.; Deste Giacomo investigator.; Valsecchi Paolo investigator.; Carpiniello Bernardo investigator.; Tusconi Massimo investigator.; Puddu Laura investigator.; Signorelli Maria Salvina investigator.; Cannavò Dario investigator.; Minutolo Giuseppe investigator.; Corbo Mariangela investigator.; Montemitro Chiara investigator.; Baroni Gaia investigator.; Altamura Mario investigator.; La Montagna Maddalena investigator.; Carnevale Raffaella investigator.; Murri Martino Belvederi investigator.; Calcagno Pietro investigator.; Bugliani Michele investigator.; Pizziconi Giulia investigator.; Logozzo Francesca investigator.; Rossi Rodolfo investigator.; Giusti Laura investigator.; Salza Anna investigator.; Malavolta Maurizio investigator.; Orsenigo Giulia investigator.; Grassi Silvia investigator.; De Bartolomeis Andrea investigator.; Gramaglia Carla investigator.; Gattoni Eleonora investigator.; Gambaro Eleonora investigator.; Tenconi Elena investigator.; Ferronato Luisa investigator.; Collantoni Enrico investigator.; Tonna Matteo investigator.; Ossola Paolo investigator.; Gerra Maria Lidia investigator.; Carmassi Claudia investigator.; Cremone Ivan Mirko investigator.; Carpita Barbara investigator.; Buzzanca Antonio investigator.; Girardi Nicoletta investigator.; Frascarelli Marianna investigator.; Del Casale Antonio investigator.; Comparelli Anna investigator.; Corigliano Valentina investigator.; Siracusano Alberto investigator.; Di Lorenzo Giorgio investigator.; Ribolsi Michele investigator.; Corrivetti Giulio investigator.; Bartoli Luca investigator.; Del Buono Gianfranco investigator.; Fagiolini Andrea investigator.; Bolognesi Simone investigator.; Goracci Arianna investigator.; Mancini Irene investigator.; Bava Irene investigator.; Cardillo Simona investigator.;
• Is Part Of: Acta psychiatrica Scandinavica. Volume 138:Number 3(2018)
• Page Start: 253
• Page End: 266
• Publication Date: 2018-07-08
• Subjects: premorbid adjustment -- primary negative symptoms -- avolition -- poor emotion expression -- cognitive functioning; Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12938
• Languages: English
• ISSNs: 0001-690X

Abstract

Abstract : Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first‐degree relatives and healthy controls. Its associations with psychopathology, cognition, and real‐life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients ( P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives ( P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real‐life functioning ( P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real‐life functioning impairment ( P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition ( P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.