Comprehensive assessment of lipoprotein subfraction profiles according to glucose metabolism status, and association with insulin resistance in subjects with early-stage impaired glucose metabolism. (15th December 2016)

• Record Type: Journal Article
• Authors: Lee, Jie-Eun; Min, Se Hee; Lee, Dong-Hwa; Oh, Tae Jung; Kim, Kyoung Min; Moon, Jae Hoon; Choi, Sung Hee; Park, Kyong Soo; Jang, Hak Chul; Lim, Soo
• Is Part Of: International journal of cardiology. Volume 225(2016)
• Page Start: 327
• Page End: 331
• Publication Date: 2016-12-15
• Subjects: Atherogenic dyslipidemia -- Lipoprotein subfraction profile -- Small dense low-density lipoprotein -- Glucose metabolism -- Impaired fasting glucose; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.10.015
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Early detection of atherogenic dyslipidemia is crucial. We investigated lipoprotein subfraction parameters according to glucose metabolism status. Methods: We recruited 1255 lipid-lowering drug-naïve subjects with normal fasting glucose (NFG; n = 200, 15.9%), impaired fasting glucose (IFG; n = 443, 35.3%), or type 2 diabetes (T2D; n = 612, 48.8%). Lipoprotein subfractions (1–7) were determined by polyacrylamide gel electrophoresis, separating low-density lipoprotein (LDL) into large buoyant LDL (lbLDL, LDL1–2) and small dense LDL (sdLDL, LDL3–7). Lipoprotein subfraction parameters including the sdLDL% (LDL3–7/LDL1–7), the sdLDL/lbLDL ratio (LDL3–7/LDL1–2), and weighted LDL subfraction (LDLSF) scores, were compared between groups. Their associations with insulin resistance, estimated using the homeostasis model assessment of insulin resistance, were examined. Results: The concentrations of sdLDL particles were significantly higher in subjects with T2D and IFG than in those with NFG (15.78 ± 13.47 mg/dl and 14.60 ± 14.33 mg/dl, respectively, vs. 12.22 ± 12.31 mg/dl). Compared with those with NFG, subjects with IFG or T2D had significantly a higher sdLDL% (15.98 ± 15.26% vs. 19.50 ± 16.21% or 21.46 ± 16.81%, respectively), a higher sdLDL/lbLDL ratio (0.24 ± 0.30 vs. 0.31 ± 0.37 or 0.35 ± 0.39), and a higher LDLSF score (2.08 ± 0.91 vs. 2.30 ± 1.14 or 2.36 ± 1.17). These lipoprotein subfraction parameters had stronger associations with insulin resistance compared to conventional lipid profiles in the IFG and T2D groups. Conclusions: Atherogenic dyslipidemia is initiated in an early stage of impaired glucose metabolism, when early intervention might be required.