4H-Thieno[3, 2-c]chromene based inhibitors of Notum Pectinacetylesterase. Issue 4 (15th February 2016)

• Record Type: Journal Article
• Authors: Han, Qiang; Pabba, Praveen K.; Barbosa, Joseph; Mabon, Ross; Healy, Jason P.; Gardyan, Michael W.; Terranova, Kristen M.; Brommage, Robert; Thompson, Andrea Y.; Schmidt, James M.; Wilson, Alan G.E.; Xu, Xiaolian; Tarver, James E.; Carson, Kenneth G.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 4(2016)
• Page Start: 1184
• Page End: 1187
• Publication Date: 2016-02-15
• Subjects: Notum Pectinacetylesterase -- Osteroporosis -- Thienochromene -- SAR -- Femur cortical bone thickness; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.01.038
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified. Abstract: A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.