Prediction of development and maintenance of high albuminuria during chronic renin–angiotensin suppression by plasma proteomics. (1st October 2015)

• Record Type: Journal Article
• Authors: Baldan-Martin, Montserrat; de la Cuesta, Fernando; Alvarez-Llamas, Gloria; Gonzalez-Calero, Laura; Ruiz-Hurtado, Gema; Moreno-Luna, Rafael; Mourino-Alvarez, Laura; Sastre-Oliva, Tamara; Segura, Julian; Padial, Luis R.; Vivanco, Fernando; Ruilope, Luis M.; Barderas, Maria G.
• Is Part Of: International journal of cardiology. Volume 196(2015)
• Page Start: 170
• Page End: 177
• Publication Date: 2015-10-01
• Subjects: CP ceruloplasmin -- HP haptoglobin -- ORM1 alpha 1-acid glycoprotein -- RAS renin–angiotensin system -- ACR albumin/creatinine ratio -- BP blood pressure -- NAG N-acetylglucosaminidase -- eGFR estimated glomerular filtration rate -- CKD chronic kidney disease -- N normoalbuminuria -- dnHA de novo high albuminuria -- SHA sustained high albuminuria -- HA high albuminuria -- VHA very high albuminuria -- iTRAQ isobaric tags for relative and absolute quantification -- LC–MS/MS liquid chromatography–tandem mass spectrometry -- ROC receiver operating characteristic -- CRP C-reactive protein -- ACEi angiotensin-converting enzyme inhibitors -- ARB angiotensin II receptor blockers -- APOA1 apolipoprotein A1 -- APOE apolipoprotein E -- SLC40A1 solute carrier family 40 member 1 -- SLC11A2 solute carrier family 11 -- TF transferrin -- Hb hemoglobin -- GBM glomerular basement membrane -- GFR glomerular filtration rate -- AER albumin excretion rate; RAS suppression -- Albuminuria -- Organ damage -- Plasma proteomics -- Hypertension; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.05.148
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: High albuminuria is a strong predictor of development of cardiovascular events in hypertensive patients. The search for predictors identifying patients at risk of developing high albuminuria or presenting a more rapid progression in this parameter may represent an effective strategy for adequate intervention and better outcome. Methods and results: Initially we investigated 24 patients presenting with normoalbuminuria, de novo albuminuria and sustained albuminuria. Plasma proteomics disclosed an upregulation of ceruloplasmin (CP), haptoglobin (HP) and alpha 1-acid glycoprotein (ORM1) that in a second step were selected for validation using turbidimetry assay in a cohort of 105 subjects. The validation showed that HP and ORM1 proteins were increased in patients presenting with very high albuminuria and potential irreversible kidney damage. CP and HP correlated positively with albuminuria values in normoalbuminuric patients. Finally, the levels of ORM1 and CP were increased in patients who progressed in their levels of albuminuria. Conclusions: Our findings show that these proteins may potentially be useful for predicting the development of high albuminuria and to monitor renal damage.