Noncoding RNAs in disease. Issue 17 (20th July 2018)

• Record Type: Journal Article
• Authors: Lekka, Evangelia; Hall, Jonathan
• Other Names: Zavolan Mihaela guestEditor.; Gerber André guestEditor.; Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 592:Issue 17(2018)
• Page Start: 2884
• Page End: 2900
• Publication Date: 2018-07-20
• Subjects: long noncoding RNA -- microRNA -- noncoding RNA; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13182
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches. Abstract :