Facile preparation of antibacterial, highly elastic silvered polyurethane nanofiber fabrics using silver carbamate and their dermal wound healing properties. (February 2017)

• Record Type: Journal Article
• Authors: Hong, Suk-Min; Kim, Jong-Wan; Knowles, Jonathan C; Gong, Myoung-Seon
• Is Part Of: Journal of biomaterials applications. Volume 31:Number 7(2017:Mar.)
• Page Start: 1026
• Page End: 1038
• Publication Date: 2017-02
• Subjects: Isosorbide -- elastomeric polyurethane -- dermal wound healing -- electrospun nanofibers -- silver nanoparticles -- silver carbamate -- thermal reduction; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328216687665
• Languages: English
• ISSNs: 0885-3282

Abstract

In this study, polycarbonate diol/isosorbide-based antibacterial polyurethane nanofiber fabrics containing Ag nanoparticles were prepared by electrospinning process. Bio-based highly elastic polyurethane was prepared from hexamethylene diisocyanate and isosorbide/polycarbonate diol (8/2) by a simple one-shot bulk polymerization. Ag nanoparticles were formed using simple thermal reduction of silver 2-ethylhexylcarbamate at 120℃. The structural and morphological properties of polyurethane/Ag nanofibers were characterized by X-ray diffraction and scanning electron microscopy. The polyurethane nanofiber fabrics were flexible, with breaking strains from 355% to 950% under 7.28 to 23.1 MPa tensile stress. The antibacterial effects of the treated polyurethane/Ag fabrics against Staphylococcus aureus and methicillin resistant Staphylococcus aureus were examined and found to be excellent. Cell proliferation using the immortalized human keratinocyte HaCaT cell line was performed in order to determine cell viability in the presence of polyurethane and polyurethane/Ag fabrics, showing cytocompatiblility and a lack of toxicity.