Joining the dots – protein‐RNA interactions mediating local mRNA translation in neurons. Issue 17 (16th June 2018)

• Record Type: Journal Article
• Authors: Gallagher, Christopher; Ramos, Andres
• Other Names: Zavolan Mihaela guestEditor.; Gerber André guestEditor.; Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 592:Issue 17(2018)
• Page Start: 2932
• Page End: 2947
• Publication Date: 2018-06-16
• Subjects: axon -- dendrite -- mRNA local translation -- mRNA transport -- neuron -- neuronal development -- protein‐RNA interactions -- RNA recognition -- RNA‐binding domain -- RNA‐binding protein; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13121
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Establishing and maintaining the complex network of connections required for neuronal communication requires the transport and in situ translation of large groups of mRNAs to create local proteomes. In this Review, we discuss the regulation of local mRNA translation in neurons and the RNA‐binding proteins that recognise RNA zipcode elements and connect the mRNAs to the cellular transport networks, as well as regulate their translation control. However, mRNA recognition by the regulatory proteins is mediated by the combinatorial action of multiple RNA‐binding domains. This increases the specificity and affinity of the interaction, while allowing the protein to recognise a diverse set of targets and mediate a range of mechanisms for translational regulation. The structural and molecular understanding of the interactions can be used together with novel microscopy and transcriptome‐wide data to build a mechanistic framework for the regulation of local mRNA translation. Abstract :