Total intravenous anesthesia produces outcomes superior to those with combined intravenous–inhalation anesthesia for laparoscopic gynecological surgery at high altitude. (February 2017)

• Record Type: Journal Article
• Authors: Xu, Rui; Zhou, Shuqin; Yang, Jin; Li, Haiyan; Zhang, Qingguo; Zhang, Guohong; Xu, Shiyuan; Peng, Qing
• Is Part Of: Journal of international medical research. Volume 45:Number 1(2017)
• Page Start: 246
• Page End: 253
• Publication Date: 2017-02
• Subjects: TIVA -- laparoscopy -- gynecological surgery -- anesthesia -- intravenous–inhalation anesthesia -- postoperative recovery; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060516687230
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: We compared efficacy and adverse outcomes following totally intravenous anesthesia (TIVA) versus combined intravenous–inhalation anesthesia (CIVIA) on hemodynamics and postoperative recovery following laparoscopic gynecological (LG) surgery at high altitudes. Methods: We enrolled 80 ASA I or II patients scheduled for LG surgery and randomly assigned them to TIVA with propofol (group P, n = 40) or CIVIA with isoflurane (group I, n = 40). Mean arterial pressure, heart rate, pulse oxygen saturation, and partial pressure of end-tidal carbon dioxide were measured at various time points. Outcome measures were interval to spontaneous ventilation, eye opening, return to consciousness, extubation, operating room duration. Intraoperative awareness and postoperative nausea/vomiting were assessed at follow-up. Results: No differences in hemodynamic parameters were detected in either group. Group P had a significantly shorter postoperative anesthetic recovery time and lower incidence of postoperative nausea/vomiting. Conclusion: TIVA is superior to CIVIA for GL surgery at high altitudes.