Association of obesity and risk of diabetic retinopathy in diabetes patients: A meta-analysis of prospective cohort studies. Issue 32 (August 2018)

• Record Type: Journal Article
• Authors: Zhu, Wei; Wu, Yan; Meng, Yi-Fang; Xing, Qian; Tao, Jian-Jun; Lu, Jiong
• Other Names: Tusconi. Massimo section editor.
• Is Part Of: Medicine. Volume 97:Issue 32(2018)
• Publication Date: 2018-08
• Subjects: body mass index -- diabetic retinopathy -- meta-analysis -- obesity -- risk factor; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011807
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Diabetic retinopathy (DR) was considered to be a common complication of diabetes. The purpose of the current study was to investigate the potential association between obesity and DR risk by conducting a meta-analysis of prospective studies. Methods: A consummate literature search of PubMed, EMBASE, and web of science was conducted until July 2016. A total of 13 prospective cohort studies were included in this meta-analysis. Results: On meta-analysis of all the studies assessing DR risk, obesity was associated with a significant increase in DR incidence (relative risk [RR], 1.20; 95% confidence interval [CI], 1.01–1.43; I 2 = 59.6%). When only proliferative DR (PDR) was considered, no significant association between obesity and risk of PDR was detected. Significant harmful effect was detected in type 2 diabetes mellitus (T2DM) group (RR, 1.40; 95% CI, 1.05–1.87; I 2 = 67.6%) but not mixed group (RR, 1.04; 95% CI, 0.97–1.18; I 2 = 0.00%). No significant publication bias was detected in the selected 13 studies. Conclusion: Obesity was a risk factor for non-proliferative DR. However additional well-designed and well-conducted epidemiologic studies were required to deepen our understanding of the relation between obesity and DR.