The colorectal cancer immune paradox revisited. (1st February 2016)

• Record Type: Journal Article
• Authors: Angelova, Mihaela; Charoentong, Pornpimol; Hackl, Hubert; Trajanoski, Z.
• Is Part Of: Oncoimmunology. Volume 5:Number 2(2016)
• Publication Date: 2016-02-01
• Subjects: Immune escape -- immunophenotype -- tumor heterogeneity; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1078058
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Tumor infiltrating lymphocytes (TILs) represent a strong independent predictor of relapse and overall survival in colorectal cancer (CRC). However, it appears that a majority of CRCs, i.e., microsatellite stable (MSS) tumors, are refractory to immune checkpoint blockers. The results of recent comprehensive analyses of genomic data provide possible answers.