Disruption of evasive immune cell microenvironment in tumors reflects immunity induced by radiation therapy. (1st February 2016)

• Record Type: Journal Article
• Authors: Filatenkov, Alexander; Baker, Jeanette; Strober, Samuel
• Is Part Of: Oncoimmunology. Volume 5:Number 2(2016)
• Publication Date: 2016-02-01
• Subjects: CD8 T cells -- colon tumors -- radiation therapy -- tumor immunity -- tumor microenvironment; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1072673
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Radiation administered to murine colon tumors induced durable remissions that were dependent on CD4 + and CD8 + T cell immunity, and antigen cross priming CD8 + dendritic cells (DCs). Remissions were associated with marked reductions in the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and Treg cells, and a marked increase in CD8 + T cells.