Meta-analysis of intravoxel incoherent motion magnetic resonance imaging in differentiating focal lesions of the liver. Issue 34 (August 2018)

• Record Type: Journal Article
• Authors: Wu, Hongzhen; Liang, Yingying; Jiang, Xinqing; Wei, Xinhua; Liu, Yu; Liu, Weifeng; Guo, Yuan; Tang, Wenjie
• Other Names: Chen. Weina section editor.
• Is Part Of: Medicine. Volume 97:Issue 34(2018)
• Publication Date: 2018-08
• Subjects: diffusion-weighted magnetic resonance imaging -- liver neoplasms -- magnetic resonance imaging -- meta-analysis -- perfusion-weighted magnetic resonance imaging; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000012071
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Introduction: Accurate detection and characterization of focal liver lesions, including differentiation between malignant and benign lesions, are particularly important. The objective of this meta-analysis was to evaluate the parameters of intravoxel incoherent motion (IVIM), including apparent diffusion coefficient (ADC), pure molecular diffusion coefficient ( D ), perfusion-related diffusion coefficient ( D *), and perfusion fraction ( f ) in differentiating focal liver lesions. Methods: IVIM method employed for focal liver lesion and the quality assessment of diagnostic studies were evaluated. Standardized mean differences and 95% confidence intervals were calculated. The heterogeneity was quantified with the I 2 statistic. Results: The difference between groups was analyzed according to the I 2 values from 6 different studies using fixed effects or random effects models. Significant differences in ADC ( P < .001) and D ( P < .001) were observed between benign and malignant lesions. Moreover, significant differences in ADC ( P < .001), D ( P < .001), and f ( P = .01) were found between hemangioma and hepatocellular carcinoma (HCC). In addition, no significant difference was observed between the metastases and HCC. Conclusions: D and ADC values were useful for the differentiation between benignity and malignancy; higher values of ADC, D, and f were observed in hemangioma compared to HCC. Nevertheless, IVIM did not result as the optimal approach for differentiation between the metastases and HCC.