Identification and derivatization of selected cathinones by spectroscopic studies. (September 2016)

• Record Type: Journal Article
• Authors: Nycz, Jacek E.; Pazdziorek, Tadeusz; Malecki, Grzegorz; Szala, Marcin
• Is Part Of: Forensic science international. Volume 266(2016)
• Page Start: 416
• Page End: 426
• Publication Date: 2016-09
• Subjects: Cathinone -- Thionation -- Lawesson reagent -- P4S10 -- Aminoguanidine -- Guanidine; Medical jurisprudence -- Periodicals; Chemistry, Forensic -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Chimie légale -- Périodiques; Gerechtelijke geneeskunde; Gerechtelijke chemie; Gerechtelijke psychiatrie; Chemistry, Forensic; Medical jurisprudence; Electronic journals; Periodicals; Electronic journals; 614.1
• DOI: 10.1016/j.forsciint.2016.06.034
• Languages: English
• ISSNs: 0379-0738

Abstract

Graphical abstract: Highlights: ⿢ Three HCl salts of cathinones have been characterized by X-ray crystallography. ⿢ Three HCl salts of cathinones have been identified by GC⿿MS, IR, NMR and UV⿿vis. ⿢ The use of thionation reactions for identification of selected cathinones. Abstract: In this study we identified three novel hydrochloride salts of cathinones 2-(pyrrolidin-1-yl)-1-(5, 6, 7, 8-tetrahydronaphthalen-2-yl)pentan-1-one (1a) (TH-PVP), 2-(methylamino)-1-(2-methylphenyl)-1-propanone (1b) (2-MMC) and 1-(4-chlorophenyl)-2-(methylamino)propan-1-one (1c) (4-CMC). Their properties have been examined through combinations of GC⿿MS, IR, NMR, electronic absorption spectroscopy and single crystal X-ray diffraction method. NMR solution spectra showed readily diagnostic H-1 and C-13 signals from methyl, N -methyl and carbonyl groups. Additionally the use of thionation and amination reactions for identification of selected cathinones was presented.