Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative ⿿NE-CHMIMO⿿ using flash chromatography, GC-MS, IR and NMR spectroscopy. (September 2016)

• Record Type: Journal Article
• Authors: Angerer, Verena; Bisel, Philippe; Moosmann, Bjoern; Westphal, Folker; Auwärter, Volker
• Is Part Of: Forensic science international. Volume 266(2016)
• Page Start: e93
• Page End: e98
• Publication Date: 2016-09
• Subjects: Herbal blends -- Designer drugs -- New psychoactive substances -- Cannabimimetics -- Spice; Medical jurisprudence -- Periodicals; Chemistry, Forensic -- Periodicals; Forensic Medicine -- Periodicals; Médecine légale -- Périodiques; Chimie légale -- Périodiques; Gerechtelijke geneeskunde; Gerechtelijke chemie; Gerechtelijke psychiatrie; Chemistry, Forensic; Medical jurisprudence; Electronic journals; Periodicals; Electronic journals; 614.1
• DOI: 10.1016/j.forsciint.2016.05.031
• Languages: English
• ISSNs: 0379-0738

Abstract

Graphical abstract: Highlights: ⿢ NMR, GC-sIR and GC-MS data of a new synthetic cannabinoid are presented. ⿢ Isolation of the substance from a herbal blend using flash chromatography. ⿢ The new compound can be described as cyclohexyl methyl derivative of JWH-018. ⿢ The new compound was named ⿿NE-CHMIMO⿿. Abstract: Synthetic cannabinoids have become an integral part of the drugs of abuse market since many years. The most frequent form of consumption for this class of substances is smoking of herbal mixtures purchased via the Internet. In this article the identification and structure elucidation of a new synthetic cannabinoid, [1-(cyclohexylmethyl)-1 H -indol-3-yl](naphthalen-1-yl)methanone, is described. The compound was found along with 5F-ADB in a ⿿herbal mixture⿿ called ⿿Jamaican Gold Extreme⿿, which was sent to our laboratory in the context of a suspected intoxication. For isolation of the substance a flash chromatography separation was applied. Structure elucidation was performed using gas chromatography-mass spectrometry (GC-MS), gas chromatography solid-state infrared (GC-sIR) and nuclear magnetic resonance (NMR) analysis. The new compound can be described as the cyclohexyl methyl derivative of the first generation synthetic cannabinoid JWH-018, and the authors suggest to use ⿿NE-CHMIMO⿿ as a semisystematic name.