Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients. (1st January 2016)

• Record Type: Journal Article
• Authors: Zacharias, Michael; Joffe, Samuel; Konadu, Elizabeth; Meyer, Theo; Kiernan, Michael; Lessard, Darleen; Goldberg, Robert J.
• Is Part Of: International journal of cardiology. Volume 202(2016)
• Page Start: 918
• Page End: 921
• Publication Date: 2016-01-01
• Subjects: Acute heart failure -- Young vs. older patients -- Population-based study; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.09.114
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: While heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger (< 65 years) as compared with older (≥ 65 years) patients hospitalized with acute decompensated heart failure. Methods and results: We reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were < 65 years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients. Conclusion: While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.