Susceptible period of socio-emotional development affected by constant exposure to daylight. (April 2015)

• Record Type: Journal Article
• Authors: Koshiba, Mamiko; Senoo, Aya; Karino, Genta; Ozawa, Simpei; Tanaka, Ikuko; Honda, Yoshiko; Usui, Setsuo; Kodama, Tohru; Mimura, Koki; Nakamura, Shun; Kunikata, Tetsuya; Yamanouchi, Hideo; Tokuno, Hironobu
• Is Part Of: Neuroscience research. Volume 93(2015:Apr.)
• Page Start: 91
• Page End: 98
• Publication Date: 2015-04
• Subjects: AChE acetylcholine esterase -- ADHD attention deficit hyperactive disorders -- ASD autistic spectrum disorders -- ODD oppositional defiant disorder -- ChAT choline acetyltransferase -- DAT dopamine transporter -- DD constant dark -- DIA dehydroascorbic acid -- DTA diphteria toxin α subunit gene -- ipRGC intrinsically photosensitive retinal ganglion cells -- GSH glutathione -- LD light–dark cycle per 12 h -- LHb lateral habenula -- LL constant light -- mAmy medial amygdala -- NOS nitric oxide synthase -- PCA principal component analysis -- SCN suprachiasmatic nuclei -- SERT serotonin transporter -- sPVZ subparaventricular nucleus -- VLPO ventrolateral preoptic area; A susceptible period learning -- Circadian rhythm -- Socio-emotional behavior -- Alert call and whole body motion -- Multivariate analysis -- Social sensory cues; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2014.09.011
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: Constant light in early life resulted in increasing of alert behaviors in adulthood indicating a disorder in the socio-emotional development of common marmosets. The susceptible period might exist earlier than 3–5 months old. Visualization by multivariate analysis with biological factors supports studies of higher-order psychological function. Abstract: As a diurnal experimental primate, the common marmoset ( Callithrix jacchus ) has recently contributed to numerous kinds of studies of neurobiological psychiatry as an essential pre-clinical model. The marmoset matures sexually within one or two years after birth. Thus, we can observe how the primate learns and develops psycho-cognitive functions through experiences in experimental environment for a much shorter period compared to that of humans. Longer daylight exposure may affect psychological development of children. In our research, we focus on raising marmosets under constant daylight from birth until various ages. In order to quantitatively evaluate the development of higher-ordered psychological functions, we designed a system of socio-behavioral tests and multivariate correlation analysis methods based on principal component analysis. With reference to the call and typical body movement expressed during a particular social context, we statistically inferred the emotional features of the subjects. In the current literature, we review our published results showing increased alert behaviors by constant light, and then, attempted to extend our additional analysis to seek age-dependent susceptibility to constant light. We then present the neurobiological mechanisms with reference to previous research reports. The current review suggests possible existence of a susceptible period earlier than three to five month-old in the environment-induced developmental disorder model, supposedly like attention deficit hyperactive disorders (ADHD) or oppositional defiant disorder (ODD).