Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers. (July 2016)

• Record Type: Journal Article
• Authors: Lane, Kevin J.; Levy, Jonathan I.; Scammell, Madeleine K.; Peters, Junenette L.; Patton, Allison P.; Reisner, Ellin; Lowe, Lydia; Zamore, Wig; Durant, John L.; Brugge, Doug
• Is Part Of: Environment international. Volume 92/93(2016:Jul.)
• Page Start: 173
• Page End: 182
• Publication Date: 2016-07
• Subjects: Ultrafine particles -- Time-activity -- Systemic inflammation -- Particle number concentration -- Cardiovascular risk; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2016.03.013
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Long-term exposure to fine particulate matter has been linked to cardiovascular disease and systemic inflammatory responses; however, evidence is limited regarding the effects of long-term exposure to ultrafine particulate matter (UFP, < 100 nm). We used a cross-sectional study design to examine the association of long-term exposure to near-highway UFP with measures of systemic inflammation and coagulation. Methods: We analyzed blood samples from 408 individuals aged 40–91 years living in three near-highway and three urban background areas in and near Boston, Massachusetts. We conducted mobile monitoring of particle number concentration (PNC) in each area, and used the data to develop and validate highly resolved spatiotemporal (hourly, 20 m) PNC regression models. These models were linked with participant time-activity data to determine individual time-activity adjusted (TAA) annual average PNC exposures. Multivariable regression modeling and stratification were used to assess the association between TAA-PNC and single peripheral blood measures of high-sensitivity C -reactive protein (hsCRP), interleukin-6 (IL-6), tumor-necrosis factor alpha receptor II (TNFRII) and fibrinogen. Results: After adjusting for age, sex, education, body mass index, smoking and race/ethnicity, an interquartile-range (10, 000 particles/cm 3 ) increase in TAA-PNC had a positive non-significant association with a 14.0% (95% CI: − 4.6%, 36.2%) positive difference in hsCRP, an 8.9% (95% CI: − 0.4%, 10.9%) positive difference in IL-6, and a 5.1% (95% CI: − 0.4%, 10.9%) positive difference in TNFRII. Stratification by race/ethnicity revealed that TAA-PNC had larger effect estimates for all three inflammatory markers and was significantly associated with hsCRP and TNFRII in white non-Hispanic, but not East Asian participants. Fibrinogen had a negative non-significant association with TAA-PNC. Conclusions: Our findings suggest an association between annual average near-highway TAA-PNC and subclinical inflammatory markers of CVD risk. Highlights: Analyzed association of long-term exposure to UFP with inflammation and coagulation biomarkers We assigned time-activity adjusted annual average PNC as exposure to UFP. We identified positive associations of TAA-PNC levels with hsCRP, IL-6 and TNFRII. Associations were stronger after adjusting for cardiovascular risk factors and race. TAA-PNC was significantly associated with hsCRP and TNFRII in white non-Hispanic.