Increased angiopoietin-like protein 8 levels in patients with type 2 diabetes and cardiovascular disease. (October 2016)

• Record Type: Journal Article
• Authors: Huang, Yun; Fang, Chen; Guo, Heming; Hu, Ji
• Is Part Of: Diabetes research and clinical practice. Volume 120(2016)
• Page Start: 229
• Page End: 231
• Publication Date: 2016-10
• Subjects: Type 2 diabetes -- Cardiovascular diseases -- Angiopoietin-like protein 8; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2016.08.017
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlight: It is the first study that evaluated the relationship between ANGPTL8 and cardiovascular diseases and provides new evidence of the involvement of ANGPTL8 in metabolic diseases. Compared with type 2 diabetes without CVD, those with CVD had remarkably higher levels of angiopoietin-like protein 8. Relationship between ANGPTL8 and CVD was independent of conventional CVD risk factors. Abstract: In the present study, we recruited 124 patients with type 2 diabetes, among which 22 had a history of cardiovascular disease (CVD). The study demonstrated that compared with type 2 diabetes without CVD, those with CVD had remarkably higher levels of angiopoietin-like protein 8 (ANGPTL8). Moreover, the close relationship between ANGPTL8 and CVD was independent of conventional CVD risk factors.